Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EIF3I |
| Gene Name: | EIF3I |
| Protein Full Name: | Eukaryotic translation initiation factor 3 subunit |
| Alias: | EIF-3 beta; EIF3 p36; EIF3-beta; EIF3i; EIF3-p36; EIF3S2; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3, subunit I; IF32; TGF-beta receptor interacting protein 1; TRIP1; TRIP-1 |
| Mass (Da): | 36502 |
| Number AA: | 325 |
| UniProt ID: | Q1334 |
| Locus ID: | 8668 |
| COSMIC ID: | EIF3I |
| Gene location on chromosome: | 1p34.1 |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.34 |
| Commentary on involvement of protein in cancer: | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |