Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CBX4 |
| Gene Name: | CBX4 |
| Protein Full Name: | E3 SUMO-protein ligase CBX4 |
| Alias: | Chromobox 4; Chromobox protein homolog 4; Chromobox protein homologue 4; HPC2; NBP16; NS5ATP1-binding protein 16; Pc2; Polycomb 2 |
| Mass (Da): | 61368 |
| Number AA: | 560 |
| UniProt ID: | O00257 |
| Locus ID: | 8535 |
| COSMIC ID: | CBX4 |
| Gene location on chromosome: | 17q25.3 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.5 |
| Commentary on involvement of protein in cancer: | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |