Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SUPT5H |
| Gene Name: | SUPT5H |
| Protein Full Name: | Transcription elongation factor SPT5 |
| Alias: | DRB sensitivity-inducing factor large subunit; DSIF large subunit; DSIF p160; FLJ34157; SPT5H; Suppressor of Ty 5; Tat-cotransactivator 1; Tat-CT1 |
| Mass (Da): | 121000 |
| Number AA: | 1087 |
| UniProt ID: | O00267 |
| Locus ID: | 6829 |
| COSMIC ID: | SUPT5H |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.97 |
| Normal role description: | SUPT5H is a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Role of SUPT5H in cancer is unclear. |