Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFRSF11B |
| Gene Name: | TNFRSF11B |
| Protein Full Name: | Tumor necrosis factor receptor superfamily member |
| Alias: | Osteoclastogenesis inhibitory factor;Osteoprotegerin |
| Mass (Da): | 46040 |
| Number AA: | 401 |
| UniProt ID: | O00300 |
| Locus ID: | 4982 |
| COSMIC ID: | TNFRSF11B |
| Gene location on chromosome: | 8q24.12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.47 |
| Normal role description: | TNFSF11B is involved in bone homeostasis, prevention of arterial calcification, leaukocyte adhesion and inhibiting apoptosis. It is secreted and blocks RANKL and prevents osteoclast activation. It can inhibit apoptosis by binding to TRAIL. OPG expression is incrased in advanced prostate, breast and gastric cancers and may mediate resistance to apoptosis. |