Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EIF3F |
| Gene Name: | EIF3F |
| Protein Full Name: | Eukaryotic translation initiation factor 3 subunit |
| Alias: | EIF-3 epsilon; EIF3 p47 subunit; EIF3f; EIF3-p47; EIF3S5; Eukaryotic translation initiation factor 3, subunit F; IF35 |
| Mass (Da): | 37564 |
| Number AA: | 357 |
| UniProt ID: | O00303 |
| Locus ID: | 8665 |
| COSMIC ID: | EIF3F |
| Gene location on chromosome: | 11p15.4 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20035 |
| Percent of cancer specimens with mutations: | 0.17 |
| Normal role description: | Subunit of the eukaryotic initiation factor 3 (eIF3) complex, which is essential for protein synthesis initiation. Phosphorylation of EIF3F by CDK11p46 is implicated in transcription inhibition and apoptosis. Low expression levels and loss of heterozygosity found in pancreatic cancers and melanoma. Restoration of expression was associated with increased apoptosis and decreased cell proliferation. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the Atlas of Genetics in Oncology. Only one mutated sample described in the SANGER COSMIC database. |