Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FOXE1 |
| Gene Name: | FOXE1 |
| Protein Full Name: | Forkhead box protein E1 |
| Alias: | Forkhead box protein E2;Forkhead-related protein FKHL15;HFKH4;HNF-3/fork head-like protein 5;Thyroid transcription factor 2 |
| Mass (Da): | 38076 |
| Number AA: | 373 |
| UniProt ID: | O00358 |
| Locus ID: | 2304 |
| COSMIC ID: | FOXE1 |
| Gene location on chromosome: | 9q22.33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.32 |
| Gene undergoes hypermethylation: | Breast cancers; Pancreatic cancers; Cutaneous squamous cell carcinoma |
| Normal role description: | Functions as thyroid transcription factor and regulates thyroglobulin and thyroidperoxydase transcription and plays a crucial role in thyroid morphogenesis. |