Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PIK3R2 |
| Gene Name: | PIK3R2 |
| Protein Full Name: | Phosphatidylinositol 3-kinase regulatory subunit b |
| Alias: | P85; P85B; Phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3K p85-beta; PI3-kinase p85-beta; PtdIns-3-kinase p85-beta |
| Mass (Da): | 81624 |
| Number AA: | 728 |
| UniProt ID: | O00459 |
| Locus ID: | 5296 |
| COSMIC ID: | PIK3R2 |
| Gene location on chromosome: | 19q13.2-q13.4 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20496 |
| Percent of cancer specimens with mutations: | 0.53 |
| Normal role description: | PIK3R2 is a regulatory subunit for a phosphatidylinositol kinase. Binds to activated protein-tyrosine kinases, via SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. |