Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EBAG9 |
| Gene Name: | EBAG9 |
| Protein Full Name: | Receptor-binding cancer antigen expressed on SiSo |
| Alias: | EBAG9; Estrogen receptor-binding fragment-associated gene 9 protein; Receptor-binding cancer antigen expressed on SiSo cells |
| Mass (Da): | 24377 |
| Number AA: | 213 |
| UniProt ID: | O00559 |
| Locus ID: | 9166 |
| COSMIC ID: | EBAG9 |
| Gene location on chromosome: | 8q23.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | EBAG9 is a tumor-associated antigen that inhibits the growth and induced apoptosis of immune cells; therefore, enbling cancer cells to evade the immune system. Is over-expressed in many human cancers, such as: breast, female-genital, gastrointestinal, blood, lung, pancreas, liver, renal, billiary-tract, hepatic, prostate, thyroid, gall bladder, and brain cancer. It is a unusual oncoprotein in that it induces cell death, though not in the cancer cell itself. |