Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RNASET2 |
| Gene Name: | RNASET2 |
| Protein Full Name: | Ribonuclease T2 |
| Alias: | Ribonuclease 6 |
| Mass (Da): | 29481 |
| Number AA: | 256 |
| UniProt ID: | O00584 |
| Locus ID: | 8635 |
| COSMIC ID: | RNASET2 |
| Gene location on chromosome: | 6q27 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 0.19 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RNASET2 is a secreted ribonuclease. Although its mechanism of action is unknown, RNASET2 is a putative tumour suppressor gene. Transfection of the protein into ovarian tumour cell lines suppressed tumorigenicity and was able to induce cell snescence in HEY4 ovarian tumour cells at higher concentrations. Ribonuclease activity was not required for the antioncogenic role, suggesting an unknown function of the protein. Its expression has been noted to decrease in primary ovarian tumors with mutations at 6q26-qter such as deletions or rearrangements. |