Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CYR61 |
| Gene Name: | CYR61 |
| Protein Full Name: | Protein CYR61 |
| Alias: | CCN family member 1;Cysteine-rich angiogenic inducer 61;Insulin-like growth factor-binding protein 10;Protein GIG1 |
| Mass (Da): | 42027 |
| Number AA: | 381 |
| UniProt ID: | O00622 |
| Locus ID: | 3491 |
| COSMIC ID: | CYR61 |
| Gene location on chromosome: | 1p22.3 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.28 |
| Commentary on involvement of protein in cancer: | Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |