Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | E2F3 |
| Gene Name: | E2F3 |
| Protein Full Name: | Transcription factor E2F3 |
| Alias: | E2F-3; KIAA0075 |
| Mass (Da): | 49162 |
| Number AA: | 465 |
| UniProt ID: | O00716 |
| Locus ID: | 1871 |
| COSMIC ID: | E2F3 |
| Gene location on chromosome: | 6p22.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20026 |
| Percent of cancer specimens with mutations: | 0.34 |
| Found in amplified chromosomal regions in human cancers: | bladder, prostate |
| Normal role description: | MYC induces expression of the E2F gene and this ultimately plays a role in the G1/S transition. Loss of function of the E2F gene may impair the ability of the cell to replicate. E2F has also been shown to interact with the RB1 gene and, through CIP1, removes the RB1 block of cell cycle progression. |