Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BAI1 |
| Gene Name: | BAI1 |
| Protein Full Name: | Brain-specific angiogenesis inhibitor 1 |
| Alias: | Brain-specific angiogenesis inhibitor 1 |
| Mass (Da): | 173514 |
| Number AA: | 1584 |
| UniProt ID: | O14514 |
| Locus ID: | 575 |
| COSMIC ID: | BAI1 |
| Gene location on chromosome: | 8q24.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20196 |
| Percent of cancer specimens with mutations: | 1.38 |
| Normal role description: | BAl1 is a G-protein coupled receptor. It binds phosphotidylserine and triggers engulment of apoptotic cells. Similar to BAI2 and BAI3, it is a negative regulator of angiogenesis. Its is regulated by p53. Reduced in expression is correlated with progression of glioblastomas. |