Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTPRT |
| Gene Name: | PTPRT |
| Protein Full Name: | Receptor-type tyrosine-protein phosphatase T |
| Alias: | EC 3.1.3.48; KIAA0283; Protein tyrosine phosphatase, receptor type, T; Receptor-type tyrosine-protein phosphatase T; RPTPrho; RPTP-rho; R-PTP-T |
| Mass (Da): | 164346 |
| Number AA: | 1463 |
| UniProt ID: | O14522 |
| Locus ID: | 11122 |
| COSMIC ID: | PTPRT |
| Gene location on chromosome: | 20q12-q13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19907 |
| Percent of cancer specimens with mutations: | 3.03 |
| Normal role description: | PTPRT is a receptor protein tyrosine phosphatase expressed primarily in the CNS. PTPRT contains an extracellular domain thought to function in cell adhesion and two intracellular catalytic domains. Mutations in PTPRT which reduce phosphatase activity were observed in colorectal cancers which indicate a tumour suppressor role for PTPRT. |
| Commentary on involvement of protein in cancer: | Lung; Non small cell carcinoma; TRUE (50%); (3/6); Mis-sense. Small Cell Carcinoma; TRUE (33%); (1/3); Mis-sense. |