Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTDSP2 |
| Gene Name: | CTDSP2 |
| Protein Full Name: | Carboxy-terminal domain RNA polymerase II polypept |
| Alias: | Nuclear LIM interactor-interacting factor 2;Protein OS-4;Small C-terminal domain phosphatase 2;Small CTD phosphatase 2 |
| Mass (Da): | 30664 |
| Number AA: | 271 |
| UniProt ID: | O14595 |
| Locus ID: | 52468 |
| COSMIC ID: | CTDSP2 |
| Gene location on chromosome: | 10 D3; 10 70.0 cM |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.27 |
| Commentary on involvement of protein in cancer: | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |