Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IRS4 |
| Gene Name: | IRS4 |
| Protein Full Name: | Insulin receptor substrate 4 |
| Alias: | IRS-4; PY160 |
| Mass (Da): | 133768 |
| Number AA: | 1257 |
| UniProt ID: | O14654 |
| Locus ID: | 8471 |
| COSMIC ID: | IRS4 |
| Gene location on chromosome: | Xq22.3 |
| Cancer protein type: | OP/?TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19689 |
| Percent of cancer specimens with mutations: | 1.75 |
| Commonly recorded point mutations: | A640G (22); A640V (9) |
| Normal role description: | IRS4 acts as an interface between multiple growth factor RTKs (IR, IGF1R, FGFR1), and a complex network of intracellular signalling molecules containing SH2 domains. Involved in the IGF1R mitogenic signalling pathway as well as AKT signalling. May acts as negative regulators of the IGFI signalling pathway by suppressing the function of IRS1 and IRS2. |