Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EI24 |
| Gene Name: | EI24 |
| Protein Full Name: | Etoposide-induced protein 2.4 homolog |
| Alias: | Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4; P53-induced gene 8 protein; P53-induced protein 8; PIG8; TP53I8 |
| Mass (Da): | 38965 |
| Number AA: | 340 |
| UniProt ID: | O14681 |
| Locus ID: | 9538 |
| COSMIC ID: | EI24 |
| Gene location on chromosome: | 11q24 |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.28 |
| Commentary on involvement of protein in cancer: | Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy. EI24 loss is associated with tumor invasiveness. |