Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ENC1 |
| Gene Name: | ENC1 |
| Protein Full Name: | Ectoderm-neural cortex protein 1 |
| Alias: | CCL28; Ectodermal-neural cortex (with BTB-like domain); Ectoderm-neural cortex 1; ENC-1; Kelch-like 37; KLHL37; NRP/B; NRPB; Nuclear matrix protein NRP/B; Nuclear restricted protein, BTB domain-like (brain); P53-induced 10; PIG10; TP53I10 |
| Mass (Da): | 66130 |
| Number AA: | 589 |
| UniProt ID: | O14682 |
| Locus ID: | 8507 |
| COSMIC ID: | ENC1 |
| Gene location on chromosome: | 5q12-13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | OG |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | ENC1 is involved in neuronal process formation and neuronal differentiation. It is an actin binding protein and may regulated cytoskeleton structure during development. Overexpression and activity leads to brain oncogenesis. |