Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRMT5 |
| Gene Name: | PRMT5 |
| Protein Full Name: | Protein arginine N-methyltransferase 5 |
| Alias: | ANM5; HRMT1L5; IBP72; JBP1; protein arginine methyltransferase 5; SKB1; SKB1Hs |
| Mass (Da): | 72684 |
| Number AA: | 637 |
| UniProt ID: | O14744 |
| Locus ID: | 10419 |
| COSMIC ID: | PRMT5 |
| Gene location on chromosome: | 14q11.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | PRMT5 is a methyltransferase that catalyzes the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). It is known to negatively regulate cyclin E1 promoter activity and cellular proliferation. Mutations in this gene have been found in mouth cancer. |