Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CHEK1 |
| Gene Name: | CHEK1 |
| Protein Full Name: | Serine/threonine-protein kinase Chk1 |
| Alias: | CHEK1; EC 2.7.11.1 |
| Mass (Da): | 54420 |
| Number AA: | 476 |
| UniProt ID: | O14757 |
| Locus ID: | 1111 |
| COSMIC ID: | CHEK1 |
| Gene location on chromosome: | 11q24.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 1483 |
| Percent of cancer specimens with mutations: | 0.40458530007 |
| Mutations observed as inherited: | Inactivated due to mismatch repair defects in colon and endometrial cancers |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CHEK1 is a protein-serine/threonine kinase required for checkpoint-mediated cell cycle arrest. It also subsequently activates DNA repair (i.e. homologous recombination) by phosphorylating RAD51 or FANCE in response to the presence of damage or unreplicated DNA. It regulates cell cycle progression via several mechanisms: 1) phosphorylation of certain proteins such as CDC25A, CDC25B and CDC25C, promoting their degradation; 2) phosphorylation and activation of p53; 3) phosphorylation and inactivation of TLK1, which consequently prevents TLK1-dependent phosphorylation of chromatin assembly factor ASF1A; 4) phosphorylation of histones and regulating transcription of genes involved in cell-cycle progression regulation; 5) phosphorylation of RB1 to promote its interaction with E2F transcription factors and subsequent cell cycle arrest |