Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RasGRF2 |
| Gene Name: | RASGRF2 |
| Protein Full Name: | Ras-specific guanine nucleotide-releasing factor 2 |
| Alias: | GRF2; Guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras protein-specific guanine nucleotide-releasing factor 2; Ras-GRF2; RGRF2 |
| Mass (Da): | 140764 |
| Number AA: | 1237 |
| UniProt ID: | O14827 |
| Locus ID: | 5924 |
| COSMIC ID: | RASGRF2 |
| Gene location on chromosome: | 5q13; 5q14.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20216 |
| Percent of cancer specimens with mutations: | 1.26 |
| Normal role description: | RASGRF2 is a calcium/calmodulin-dependent guanine nucleotide exchange factor specific for Ras and Rac1 monomeric G-proteins. RASGRF2 activates G-proteins by promoting the conversion of inactive GDP-bound forms to activated GTP-bound forms. RASGRF2 positively regulates G-proteins. Ras type G-proteins are involved in signalling to activate cell growth, proliferation and differentiation in response to mitogenic signals. Thus dysfunction of RASGRF2 may promote the development of cancer. Several mis-sense mutations have been detected in colorectal, breast, ovary and skin cancer. Although these mutations have not been characterized functionally it may promote RASGRF2 mediated activation of Ras proteins to induce cellular growth and proliferation. |
| Commentary on involvement of protein in cancer: | Less than 3% mutation in CNS and breast. |