Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AIM2 |
| Gene Name: | AIM2 |
| Protein Full Name: | Interferon-inducible protein AIM2 |
| Alias: | Absent in melanoma 2; PYHIN4 |
| Mass (Da): | 38954 |
| Number AA: | 343 |
| UniProt ID: | O14862 |
| Locus ID: | 9447 |
| COSMIC ID: | AIM2 |
| Gene location on chromosome: | 1q23.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.56 |
| Normal role description: | AIM2 expression isinduced by interferon-gamma signalling and leads to the formation of the inflammasome. Ultimately, AIM2 leads to apoptosis via caspase pathways. |