Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRIM24 |
| Gene Name: | TRIM24 |
| Protein Full Name: | Transcription intermediary factor 1-alpha |
| Alias: | HTIF1; Kinase TIF1-alpha; RNF82; TIF1; Tif1; TIF1A; Tif1a; Transcription intermediary factor 1-alpha; Transcriptional intermediary factor 1 (PTC6,TIF1A); Transcriptional intermediary factor 1 (PTC6;TIF1A); Trim24; Tripartite motif protein 24; Tripartite motif-containing 24 |
| Mass (Da): | 116831 |
| Number AA: | 1050 |
| UniProt ID: | O15164 |
| Locus ID: | 8805 |
| COSMIC ID: | TRIM24 |
| Gene location on chromosome: | 7q34 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20330 |
| Percent of cancer specimens with mutations: | 0.83 |
| Deregulated in translocations: | t(7;8)(q34;p11) in leukemia --> TRIM24 - FGFR1; t(7;10)(q34;q11) in papillary thyroid carcinoma: --> TRIM24- RET |
| Normal role description: | The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. TRIO promotes ubiquitination and proteasomal degradation of p53/TP53. TRIM24 may induce oncogenesis by decreasing levels of pro-apoptotic proteins and promoting proliferation and anabolism through steroid pathways. Chimeric proteins containing TRIM24 appear to promote tumour progression via other mechanisms unrelated to the normal role of this protein (eg. constituent kinase activity with RET fusion) |