Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPK13 |
| Gene Name: | MAPK13 |
| Protein Full Name: | Mitogen-activated protein kinase 13 |
| Alias: | EC 2.7.1.37; EC 2.7.11.24; MAP kinase p38 delta; MAPK13; Mitogen-activated protein kinase p38 delta; MK13; P38 MAPK-delta; P38delta; PRKM13; SAPK4; Stress-activated protein kinase-4 |
| Mass (Da): | 42090 |
| Number AA: | 365 |
| UniProt ID: | O15264 |
| Locus ID: | 5603 |
| COSMIC ID: | MAPK13 |
| Gene location on chromosome: | 6p21.31 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20680 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | MAPK13 is a protein-serine/threonine kinase. It is actvated by cytokines and stresses and affects proliferation, differentiation, transcription regulation, translation regulation, cytoskeleton regulation, insulin secretion, cell survival and development. It can be a positive or negative regulator of the above processes depending on the cell context. Increased expression has been associated with increases proliferation and metastatic progression. It is also hypermethylated in some cancer cell lines. |