Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPM1D |
| Gene Name: | PPM1D |
| Protein Full Name: | Protein phosphatase 1D |
| Alias: | P53-induced PP1; PP2C-delta; Protein phosphatase magnesium-dependent 1 delta; WIP1 |
| Mass (Da): | 66675 |
| Number AA: | 605 |
| UniProt ID: | O15297 |
| Locus ID: | 8493 |
| COSMIC ID: | PPM1D |
| Gene location on chromosome: | 17q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19837 |
| Percent of cancer specimens with mutations: | 0.57 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | primary breast cancers (15%) |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PPM1D is a protein serine/threonine phosphatase. It dephosphorylates p53 and allows for the progression of the cell cycle. Amplification of the gene has been noted in breast cancer. |