Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | INPPL1 |
| Gene Name: | INPPL1 |
| Protein Full Name: | Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| Alias: | IQ motif containing GTPase activating protein 2; IQGA2 |
| Mass (Da): | 180613 |
| Number AA: | 1258 |
| UniProt ID: | O15357 |
| Locus ID: | 3636 |
| COSMIC ID: | INPPL1 |
| Gene location on chromosome: | 11q13.4 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.98 |
| Normal role description: | INPPL1 is a SH2-containing 5'-inositol phosphatase. It is involved in the regulation of insulin function. INPPl1 also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. INPPL1 is also a marker for breast cancer, as it supports growth and metastisis of breast neoplasms. |