Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HDAC3 |
| Gene Name: | HDAC3 |
| Protein Full Name: | Histone deacetylase 3 |
| Alias: | HD3; RPD3; RPD3-2; SMAP45 |
| Mass (Da): | 48848 |
| Number AA: | 428 |
| UniProt ID: | O15379 |
| Locus ID: | 8841 |
| COSMIC ID: | HDAC3 |
| Gene location on chromosome: | 5q31.3 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | HDAC3 removes acetly groups from histones. This HDAC represses transcription when tethered to a promoter and can downregulate the tumour suppressor p53, thus making it an oncoprotein. Mutation in HDAC3 have been implicated in numerous tumors typoes. |