Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GRIN2D |
| Gene Name: | GRIN2D |
| Protein Full Name: | Glutamate [NMDA] receptor subunit epsilon-4 |
| Alias: | EB11; Estrogen receptor binding CpG island; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D; GRIN2D; NMDE4; N-methyl D-aspartate receptor 2D; NR2D |
| Mass (Da): | 143752 |
| Number AA: | 1336 |
| UniProt ID: | O15399 |
| Locus ID: | 2906 |
| COSMIC ID: | GRIN2D |
| Gene location on chromosome: | 19q13.1-qter |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19788 |
| Percent of cancer specimens with mutations: | 0.69 |
| Normal role description: | GRIN2D is a glutamate-gated ion channel, that shows voltage-dependent sensitivity for magnesium and and a high permability for calcium. Synaptic NMDA receptors were shown to have antiapoptotic acitivity, whereas extrasynaptic NMDA receptor are involved in causing cell death. |