Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CFLAR |
| Gene Name: | CFLAR |
| Protein Full Name: | CASP8 and FADD-like apoptosis regulator |
| Alias: | CASH; CASP8AP1; Caspase homologue; Caspase-eight-related; Caspase-like apoptosis regulatory; Caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory; C-FLIP; C-FLIPL; C-FLIPR; CLARP; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; FLIP; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; Usurpin; Usurpin beta |
| Mass (Da): | 55344 |
| Number AA: | 480 |
| UniProt ID: | O15519 |
| Locus ID: | 8837 |
| COSMIC ID: | CFLAR |
| Gene location on chromosome: | 2q33.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | MIXED |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.26 |
| Transduced into viral genome: | HHV-8 |
| Normal role description: | CFLAR has close homology to Caspase 8 but lacks caspase catalytic activity. Thus, CFLAR functions as a competitive inhibitor of the caspase pathway. CFLAR will therefore block Fas- and TNF-a mediate cell apoptosis. Howoever, some mutant variants have demonstrated oposite effect and trigger apoptosis. |