Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Per1 |
| Gene Name: | PER1 |
| Protein Full Name: | Period circadian protein homolog 1 |
| Alias: | Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; hPER; KIAA0482; PER; period 1; Period circadian protein 1; RIGUI |
| Mass (Da): | 136212 |
| Number AA: | 1290 |
| UniProt ID: | O15534 |
| Locus ID: | 5187 |
| COSMIC ID: | PER1 |
| Gene location on chromosome: | 17p13.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 20420 |
| Percent of cancer specimens with mutations: | 0.81 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PER1 plays a role in generating circadian rhythms. It influences clock function by transporting other circadian regulatory proteins into the nucleus. Its specific function is not yet known. Overexpression of PER1 was correlated with significant growth reduction of tumour cells and sensitization to DNA damage-induced apoptosis, suggesting a tumor-suppressor role. However, its mechanism of action is not understood. |