Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PLXNB1 |
| Gene Name: | PLXNB1 |
| Protein Full Name: | Plexin-B1 |
| Alias: | KIAA0407; Plexin 5; Plexin B1; PLEXIN-B1; PLXB1; PLXN5; Semaphorin receptor; Semaphorin receptor SEP; SEP |
| Mass (Da): | 232298 |
| Number AA: | 2135 |
| UniProt ID: | O43157 |
| Locus ID: | 5364 |
| COSMIC ID: | PLXNB1 |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19783 |
| Percent of cancer specimens with mutations: | 1.3 |
| Normal role description: | Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Also demonstrated to interacts with MET RTK. Loss of function may promote metastasis by decreasing the need for anchor-dependent growth. Mutations in prostate cancer cause loss of function with associated compensatory RNA overexpression. |