Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADAM12 |
| Gene Name: | ADAM12 |
| Protein Full Name: | Disintegrin and metalloproteinase domain-containin |
| Alias: | Meltrin-alpha |
| Mass (Da): | 99641 |
| Number AA: | 909 |
| UniProt ID: | O43184 |
| Locus ID: | 8038 |
| COSMIC ID: | ADAM12 |
| Gene location on chromosome: | 10q26.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20030 |
| Percent of cancer specimens with mutations: | 1.11 |
| Normal role description: | ADAM12 is a disintegrin and a metalloprotease. It cleaves grow-factor binding proteins (IGFBP-3 and IGFBP-5) as well as heparin-bound EGF binding proteins. The cleavage of binding proteins leads to upregulation of cellular growth factor pathways, inhibition of apoptosis, and increased tumour proliferation. |