Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLK10 |
| Gene Name: | KLK10 |
| Protein Full Name: | Kallikrein-10 |
| Alias: | Normal epithelial cell-specific 1;Protease serine-like 1 |
| Mass (Da): | 30138 |
| Number AA: | 276 |
| UniProt ID: | O43240 |
| Locus ID: | 5655 |
| COSMIC ID: | KLK10 |
| Gene location on chromosome: | 19q13.41 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.27 |
| Gene undergoes hypermethylation: | CpG hypermethylation in breast cancer |
| Normal role description: | KLK10 is a serine protease that is secreted and may play a role in tumour suppression of breast- and prostate cancers. However, its exact enzymatical function has not yet been determined, and it is also upregulated in a number of cancers, implicating that its expression might be tissue-specific. |