Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP3K7 |
| Gene Name: | MAP3K7 |
| Protein Full Name: | Mitogen-activated protein kinase kinase kinase 7 |
| Alias: | EC 2.7.11.25; M3K7; TGF-beta-activated kinase 1 |
| Mass (Da): | 67196 |
| Number AA: | 606 |
| UniProt ID: | O43318 |
| Locus ID: | 6885 |
| COSMIC ID: | MAP3K7 |
| Gene location on chromosome: | 6q15 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.51 |
| Normal role description: | MAP3K7 is a protein-serine/threonine kinase that is activated by proinflammatory cytokines and in response to physical/chemical stress, including UVR, osmotic- and oxidative stress. It is a mediator of TRAF6 and TGF-β signal transduction, and activates IKBKB and MAPK8 in response to TRAF6 signalling. It also stimulates NFκB activation and activation of the p38 MAPK pathway. It is responsible for controlling a variety of cell functions such as transcription and apoptosis. MAP3K7 is important for TGF-β1 regulation of MMP9 and the metastatic potential of certain breast cancer cell lines. |