Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CBFA2T2 |
| Gene Name: | CBFA2T2 |
| Protein Full Name: | Protein CBFA2T2 |
| Alias: | Core-binding factor, runt domain, alpha subunit 2; EHT; ETO homologous on chromosome 20; MT8R; MTG8-like protein; MTG8R; MTG8-related protein 1; MTGR1; Myeloid translocation related protein 1; P85; Translocated to, 2; ZMYND3 |
| Mass (Da): | 67133 |
| Number AA: | 604 |
| UniProt ID: | O43439 |
| Locus ID: | 9139 |
| COSMIC ID: | CBFA2T2 |
| Gene location on chromosome: | 20q11 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.47 |
| Commentary on involvement of protein in cancer: | May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. |