Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | XRCC3 |
| Gene Name: | XRCC3 |
| Protein Full Name: | DNA repair protein XRCC3 |
| Alias: | DNA repair protein XRCC3; RAD51-like; X-ray repair complementing defective repair in Chinese hamster cells 3 |
| Mass (Da): | 37850 |
| Number AA: | 346 |
| UniProt ID: | O43542 |
| Locus ID: | 7517 |
| COSMIC ID: | XRCC3 |
| Gene location on chromosome: | 14q32.3 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.18 |
| Normal role description: | XRCC3 is a DNA repair protein required for repair of double strand breaks by nonhomologous end joining and repair of DNA cross-linking. XRCC3 has been found to interact with RAD51 and RAD51C to be recruited to sites of DNA damage. Mis-sense mutations in XRCC3 have been found to correlate with the development of breast cancer and malignant melanomas. In general the mutations were found to cause lower DNA repair activity. However there is a lack of consensus into associations of XRCC3 dysfunction with cancer development in the literature. |