Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DENR |
| Gene Name: | DENR |
| Protein Full Name: | Density-regulated protein |
| Alias: | Density-regulated; DRP; DRP1; SMAP-3; Smooth muscle cell associated protein-3; Smooth muscle cell-associated 3 |
| Mass (Da): | 22092 |
| Number AA: | 198 |
| UniProt ID: | O43583 |
| Locus ID: | 8562 |
| COSMIC ID: | DENR |
| Gene location on chromosome: | 12q24.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.08 |
| Normal role description: | DENR contains SUI-1 domain is found to interact in mRNA regulations. It may be involved in directing ribosome to start site of translation. It has an important role in modulating the translational profile of a cell. In cancer it has been found to interacto with MCTS1 to alter translation of cancer-related transcripts. |