Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SNAI2 |
| Gene Name: | SNAI2 |
| Protein Full Name: | Zinc finger protein SNAI2 |
| Alias: | SLUG, SLUGH |
| Mass (Da): | 29986 |
| Number AA: | 268 |
| UniProt ID: | O43623 |
| Locus ID: | 6591 |
| COSMIC ID: | SNAI2 |
| Gene location on chromosome: | 8q11.21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | SNAI2 is a transcriptional regulator. It represses expression of E-cadherin. Mutation and deletions of these gene increases risk of cancer and is associated with epithelial to mesenchymal transition in tumors. |