Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PSCA |
| Gene Name: | PSCA |
| Protein Full Name: | Prostate stem cell antigen |
| Mass (Da): | 12912 |
| Number AA: | 123 |
| UniProt ID: | O43653 |
| Locus ID: | 8000 |
| COSMIC ID: | PSCA |
| Gene location on chromosome: | 8q24.3 |
| Cancer protein type: | OP/TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | PSCA is a GPI-anchored cell membrane glycoprotein thought to be involved in cell proliferation regulation, and it has been shown to have an inhibitory effect on cell-proliferation in vitro. The gene is commonly up-regulated in prostate cancer, as well as in bladder-, renal-, pancreatic- and diffuse-type gastric cancer. However, it has also been found to be down-regulated in certain gastric cancers. A polymorphism in the gene that results in an upstream start codon in some individuals has been associated with an increased risk for certain gastric-, and bladder cancers. |