Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TLX3 |
| Gene Name: | TLX3 |
| Protein Full Name: | T-cell leukemia homeobox protein 3 |
| Alias: | Homeobox protein Hox-11L2 |
| Mass (Da): | 31867 |
| Number AA: | 291 |
| UniProt ID: | O43711 |
| Locus ID: | 30012 |
| COSMIC ID: | TLX3 |
| Gene location on chromosome: | 5q35.1 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.29 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(5;14)(q35;q32) with BCL11B and t(5;14)(q35;q11) with TCRD in T-cell acute lymphocytic leukemia |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TLX3 is a homeobox protein involved in the development of the mdullary respiratory center. A t(5;14)(q35;q32) translocation that disrupts its expression regulation is involved in T-cell acute lymphoblastic leukemia and is associated with a poor prognosis. |