Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRIAP1 |
| Gene Name: | TRIAP1 |
| Protein Full Name: | TP53-regulated inhibitor of apoptosis 1 |
| Alias: | Protein 15E1.1;WF-1;p53-inducible cell-survival factor |
| Mass (Da): | 8786 |
| Number AA: | 76 |
| UniProt ID: | O43715 |
| Locus ID: | 51499 |
| COSMIC ID: | TRIAP1 |
| Gene location on chromosome: | 12q24.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.03 |
| Normal role description: | TRIAP1 is a protein involved in inhibition of apoptosis. TRIAP1 is activated in response to normal cellular conditions by p53. TRIAP1 will interact with APAF1 and HSP70 to inhibit activation of caspase-9 and promote cell survival. TRIAP1 over expression has been implicated in the development of multiple myeloma. |