Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUAK1 |
| Gene Name: | NUAK1 |
| Protein Full Name: | NUAK family SNF1-like kinase 1 |
| Alias: | AMP-activated protein kinase family member 5; ARK5; EC 2.7.11.1; KIAA053; KIAA0537; Kinase NuaK1; NUAK family, SNF1-like kinase, 1; NUAK2; Probable KIAA0537 |
| Mass (Da): | 74305 |
| Number AA: | 661 |
| UniProt ID: | O60285 |
| Locus ID: | 9891 |
| COSMIC ID: | NUAK1 |
| Gene location on chromosome: | 12q23.3 |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | NUAK1 is a protein-serine/threonine kinase. Involved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR. |