Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZEB2 |
| Gene Name: | ZEB2 |
| Protein Full Name: | Zinc finger E-box-binding homeobox 2 |
| Alias: | KIAA0569; SIP1; SIP-1; Smad interacting-protein 1; Smad-interacting 1; Smad-interacting protein 1; SMADIP1; ZEB2; ZFX1B; Zinc finger E-box binding homeobox 2; Zinc finger E-box-binding 2; Zinc finger homeobox 1b; Zinc finger homeobox protein 1b |
| Mass (Da): | 136447 |
| Number AA: | 1214 |
| UniProt ID: | O60315 |
| Locus ID: | 9839 |
| COSMIC ID: | ZEB2 |
| Gene location on chromosome: | 2q22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20644 |
| Percent of cancer specimens with mutations: | 1.58 |
| Normal role description: | Encodes for a transcriptional repressor, which interacts with activated SMADs. Binds to the DNA sequence 5'-CACCT-3' and represses transcription of E-cadherin. |