Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KIF1B |
| Gene Name: | KIF1B |
| Protein Full Name: | Kinesin family member 1B |
| Alias: | KIF1Bbeta; Kinesin family member 1Bbeta isoform I |
| Mass (Da): | 205140 |
| Number AA: | 1823 |
| UniProt ID: | O60333 |
| Locus ID: | 23095 |
| COSMIC ID: | KIF1B |
| Gene location on chromosome: | 1p36.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19745 |
| Percent of cancer specimens with mutations: | 1.37 |
| Normal role description: | KIF1B is a motor protein that helps transport synaptic vesicle-precursors and mitochondria. Mutations in this gene have been found in mouth and ovarian tumors. |
| Commentary on involvement of protein in cancer: | Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. |