Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PHLPP1 |
| Gene Name: | PHLPP1 |
| Protein Full Name: | PH domain leucine-rich repeat-containing protein p |
| Alias: | KIAA0606; pleckstrin homology domain containing family E protein; PLEKHEI, SCOP |
| Mass (Da): | 184672 |
| Number AA: | 1717 |
| UniProt ID: | O60346 |
| Locus ID: | 23239 |
| COSMIC ID: | PHLPP1 |
| Gene location on chromosome: | 18q21.33 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19740 |
| Percent of cancer specimens with mutations: | 0.77 |
| Normal role description: | Specifically dephosphorylates the pro-survival kinase Akt and PKC isoforms. Dephosphorylation of Akt leads to apoptosis, dephosphorylation of PKC to their destabilization and degradation.Involved in regulation of cell survival and apoptosis. May act as a negative regulator of K-Ras signalling in membrane rafts. Suggested to have tumour suppressor function. |