Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CCNT1 |
| Gene Name: | CCNT1 |
| Protein Full Name: | Cyclin-T1 |
| Alias: | CCNT; Cyclin T1; Cyclin-T; CycT1; HIVE1 |
| Mass (Da): | 80685 |
| Number AA: | 726 |
| UniProt ID: | O60563 |
| Locus ID: | 904 |
| COSMIC ID: | CCNT1 |
| Gene location on chromosome: | 12q13.11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19906 |
| Percent of cancer specimens with mutations: | 0.55 |
| Normal role description: | Cyclin T1 can associate with CDK9 kinase, and is a major subunit of the transcription elongation factor p-TEFb, which, when complexed, can interact and act as a cofactor for HIV-1 Tat protein, thereby increasing Tat's affinity for the transactivating response RNA element. CCNT1 is necessary for full activation of viral transcription; the complex is involved in the phosphorylation and regulation of the C-terminal domain of the largest RNA polymerase II subunit, allowing transcription of viral genes. |
| Commentary on involvement of protein in cancer: | 1/199 lung cancer samples was mutated (mis-sense) |