Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTNND1 |
| Gene Name: | CTNND1 |
| Protein Full Name: | Catenin delta-1 |
| Alias: | Cadherin-associated Src substrate; CAS; CATNS; CTD1; CTND1; KIAA0384; p120 catenin |
| Mass (Da): | 108170 |
| Number AA: | 968 |
| UniProt ID: | O60716 |
| Locus ID: | 1500 |
| COSMIC ID: | CTNND1 |
| Gene location on chromosome: | 11q12.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19851 |
| Percent of cancer specimens with mutations: | 0.9 |
| Normal role description: | Binds catenins and thereby contributes to stabilization of adherens junctions. Is involved in rearrangement of actin cytoskeleton through regulation of Rho family members. Stabilizes E-Cadherin, a tumour suppressor and may be further involved in tumour and metastasis suppression. Loss or downregulation of expression of p120 is often found in various types of cancers. May interact with transcriptional repressor Kaiso in the Wnt-pathway (hyperactive in colon cancer) and was suggested to be required in anchor-independet growth. |