Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DKC1 |
| Gene Name: | DKC1 |
| Protein Full Name: | Uncharacterized protein |
| Alias: | CBF5 homolog; Dyskerin; H/ACA ribonucleoprotein complex subunit 4; Nopp140-associated protein of 57 kDa; Nucleolar protein family A member 4; Nucleolar protein NAP57; SnoRNP protein DKC1 |
| Mass (Da): | 57627 |
| Number AA: | 514 |
| UniProt ID: | O60832 |
| Locus ID: | 1736 |
| COSMIC ID: | DKC1 |
| Gene location on chromosome: | Xq28 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | DKC1 is a small nucleolar ribonucleoprotein. It is involved in rRNA processing, telomerase maintenance and ribosome processing. |