Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GAS7 |
| Gene Name: | GAS7 |
| Protein Full Name: | Growth arrest-specific protein 7 |
| Alias: | GAS-7; Growth arrest-specific 7; Growth-arrest-specific 7 |
| Mass (Da): | 54371 |
| Number AA: | 476 |
| UniProt ID: | O60861 |
| Locus ID: | 8522 |
| COSMIC ID: | GAS7 |
| Gene location on chromosome: | 17p13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20357 |
| Percent of cancer specimens with mutations: | 0.58 |
| Deregulated in translocations: | treatment-related acute non lymphocytic leukemia with t(11;17)(q23;p13); 5' MLL-3' GAS7 |
| Normal role description: | Expressed in terminally differentiated and/or quiescent cells. Mainly implicated in neuronal development and not particularly related to cancer. Although neuroblastoma cells that over-express GAS7 begin to look more like true differentiated neurons, the role of GAS7 as a bonafied TSP is not established. |