Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HUS1 |
| Gene Name: | HUS1 |
| Protein Full Name: | Checkpoint protein HUS1 |
| Mass (Da): | 31691 |
| Number AA: | 280 |
| UniProt ID: | O60921 |
| Locus ID: | 3364 |
| COSMIC ID: | HUS1 |
| Gene location on chromosome: | 7p12.3 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20263 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | Hus1 along with and Rad1 forms the 9-1-1 complex which is recruited to damaged DNA. Acts as scaffold for DNA repair proteins. HUS1 ntegrates into the PI3K cell signalling pathway and also arrests cell cycle progression if damaged DNA is identified. Hus1 has been shown to be upregulated in certain cancer systems, presumably as an attempt to repair damaged DNA. Moreover, inactivation of Hus1 sensitizes cancer cells to chemotherapeutic agents by allowing them to exert lethal DNA damage. Hus1 inactivation may also allow sporadic cancers to develop through genomic instability but it should be noted that the 9-1-1 complex is required for cell cycle progression; this may limit the ability of loss of function mutations to promote cancer. |