Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAB11FIP3 |
| Gene Name: | RAB11FIP3 |
| Protein Full Name: | Rab11 family-interacting protein 3 |
| Alias: | Arfophilin-1;EF hands-containing Rab-interacting protein;MU-MB-17.148 |
| Mass (Da): | 82440 |
| Number AA: | 756 |
| UniProt ID: | O75154 |
| Locus ID: | 9727 |
| COSMIC ID: | RAB11FIP3 |
| Gene location on chromosome: | 16p13.3 |
| Number of cancer specimens: | 19634 |
| Percent of cancer specimens with mutations: | 0.43 |
| Commentary on involvement of protein in cancer: | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. |